Student Chungbuk university Cheongju, Ch'ungch'ong-bukto, Republic of Korea
Abstract:
Background: Hypertriglyceridemia can partially mediate between diabetes mellitus (DM) and pancreatitis in dogs, implying that another mediator, such as chronic hyperglycemia, might exist.
Objectives: To evaluate the relationship between hyperglycemia and serum canine pancreatic lipase immunoreactivity (cPLI) concentration in diabetic dogs. Animals: Twenty-six client-owned dogs with DM were included, and the DM dogs were divided into two subgroups according to serum fructosamine level (< 500 μmol/l = good, controlled DM group; > 500 μmol/l = poorly controlled DM group).
Methods: Retrospective cohort study. Serum fructosamine and cPLI concentration were measured in all the dogs.
Results: Five of 26 dogs with DM (19.2%) had high serum cPLI concentration consistent with pancreatitis, and two of them also showed ultrasonographic evidence of pancreatitis without clinical signs. The median serum cPLI concentrations were significantly higher in poorly controlled DM group (median: 520 μg/L, range: 179.76 – 1000 μg/L) than those of well controlled DM group (median: 77 μg/L, range: 32.22 – 244.6 μg/L, P = 0.0147). Serum fructosamine concentration was positively correlated with serum cPLI concentration (r = 0.4816; P = 0.0127). Multivariate analysis showed that serum triglyceride and fructosamine concentration were associated with the serum cPLI concentration. Conclusions and clinical importance: Chronic hyperglycemia may induce pancreatic inflammation in diabetic dogs; however, the clinical significance of increased cPLI concentration is unknown.
