Internal Medicine College of Veterinary medicine, Chungnam National University Cheongju, Ch'ungch'ong-bukto, Republic of Korea
Abstract: Background –Hypomagnesemia induced by long-term use of proton-pump inhibit (PPI) is a rare but increasingly recognized complication in human medicine. However, there is a lack of information regarding the risk of hypomagnesemia in dogs with long-term use of PPI. Hypothesis/Objectives – The objectives were to investigate the ionized magnesium (iMG) in dogs with long-term use of PPI. Animals –Ten client-owned dogs with long-term esomeprazole use and thirty healthy control dogs. Methods – Retrospective study. Blood iMG concentrations were measured in each patient by ion-selective electrodes methods. Inclusion criteria were a dog use esomeprazole more than 6 months. No patient received magnesium supplementation. Results – Median duration of use for PPI was 25 months (range, 6 to 57). Mean iMg was 0.46 ± 0.05 mmol/L after long term use of PPI and 0.48 ± 0.05 mmol/L in healthy control dogs. iMg in dogs with long-term use of PPI did not show a significant difference compared to normal control groups. Hypomagnesemia was not observed in all dogs and clinical signs relating to hypomagnesemia were also not observed. Conclusions and clinical importance – Dogs with long-term use of PPI did not show hypomagnesemia compared to age-matched healthy dogs. Further investigations could confirm these findings and evaluate the risk of hypomagnesemia with long-term use of PPI.
