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ACVIM Resident Research Award Eligible
ACVIM Resident Research Award Eligible
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Additional Fees May Be Required
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By Invite Only
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Capturing for On Demand
Cardiology Research Abstract Award Eligible
Cardiology Research Abstract Award Eligible
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ERC Approved Lecture for ACVIM Residency
ePoster
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Livestream
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Pre-Registration Required
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RACE-Approved
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Research Abstract
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Specialty Symposium
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State-of-the-Art (SOTA) Presentation
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Equine

Category: Research Abstract - ePoster

(E52) Antibody Response to Equine Influenza Virus and herpesvirus-1 Vaccine in Adult Horses Receiving Intravenous Dexamethasone

Thursday, June 15, 2023
6:00 PM – 7:00 PM ET
Location: Solutions Center Poster Park - Poster Stand
ePoster

    Research Abstract – ePoster Presenter(s)

  • NK

    Nicole Kreutzfeldt, MRCVS (she/her/hers)

    Resident in Large Animal Internal Medicine (Equine Emphasis)
    Veterinary Medicine Teaching Hospital, University of California, Davis
    Davis, California, United States

Abstract:

Background: The effect of intravenous dexamethasone on the antibody response to a commercial EIV/EHV-1/EHV-4 vaccine in healthy adult horses has not been investigated.
Hypothesis: Dexamethasone will result in decreased systemic inflammatory response measured by SAA and decreased antibody titers against EIV and EHV-1 post-vaccination.
Animals: 55 healthy adult horses from the research herd of School of Veterinary Medicine, University of California, Davis.

Methods: Randomized cohort study, 4 study groups. Healthy control (group 1), vaccination only (EIV/ EHV-1, Prestige 2, Merck Animal Health, group 2), vaccination and single dose intravenous dexamethasone (20mg, group 3), vaccination and intravenous dexamethasone every 24hours for 3 doses (20mg each dose, group 4). Serum SAA levels were measured on day 1 and at 72 hours. Antibody titers against EIV (hemagglutination inhibition assay, Kentucky 2014 antigen) and EHV-1 (multiplex ELISA targeting total IgG and IgG 4/7) were measured on day 1 and day 30.

Results: Only group 2 showed a significant increase in SAA values after 72 hours (P = 0.04). There was no statistical difference between pre- and post-vaccination levels of anti-EHV-1 antibodies (P > 0.05). Group 2 and 3 showed a significant increase in anti-EIV antibody titers (P = 0.05 and P = 0.01, respectively). There was no significant difference between the anti-EIV IgG titers in other study groups.

Conclusion: Dexamethasone reduced the SAA response post EIV/EHV-1/EHV-4 vaccine but resulted in similar antibody responses to EHV-1 when compared to vaccinated horses only. A single dose of dexamethasone significantly increased the antibody response to EIV.