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ACVIM Resident Research Award Eligible
ACVIM Resident Research Award Eligible
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Small Animal Internal Medicine

Category: Research Abstract - ePoster

The role of gastrin in dogs with spontaneous primary hyperparathyroidism

(EN17) The Role of Gastrin in Dogs with Spontaneous Primary Hyperparathyroidism

Thursday, June 15, 2023
12:25 PM – 12:40 PM ET
Location: Solutions Center Poster Park - Kiosk 1
ACVIM Resident Research Award Eligible ePoster

    Research Abstract – ePoster Presenter(s)

  • JV

    Julieann Vose, DVM (she/her/hers)

    Resident, Small Animal Internal Medicine
    Michigan State University College of Veterinary Medicine
    Lansing, Michigan, United States

Abstract:

Background: Hypercalcemia has been associated with hypergastrinemia in humans. Hypergastrinemia could be responsible for gastrointestinal signs in dogs with primary hyperparathyroidism (PHPT).

Hypothesis/

Objectives: i) determine the prevalence of hypergastrinemia in dogs with PHPT, ii) assess correlation between ionized calcium (iCa) and serum gastrin concentrations, iii) determine whether gastrin concentrations decrease following treatment of PHPT.

Animals: 144 dogs with spontaneous PHPT.

Methods: Prospective study. Diagnosis of PHPT was based on medical record review. Dogs with azotemia, concurrent disease, or those receiving acid suppressants were excluded. Gastrin concentrations were quantified via radioimmunoassay. Eleven dogs had repeat quantification of gastrin, PTH, and iCa, 4 weeks after parathyroidectomy or ethanol ablation. Spearman’s rank correlation coefficients (rs) were used to evaluate association between iCa and gastrin. A paired t-test was used to assess changes in gastrin, PTH, and iCa, concentrations from baseline to 28 days post treatment.

Results: Increased gastrin concentrations (>78.9 ng/L) were found in 19.7% of dogs at PHPT diagnosis, compared to 9.1% post treatment. The median gastrin concentrations pre vs. post treatment were 49.0 ng/L (IQR: 29.5 ng/L) and 64.0 ng/L (IQR: 31.0 ng/L) respectively. PHPT treatment did not significantly alter gastrin concentrations (P = .60) but did reduce iCa (P = < .001) and PTH (P = .01) concentrations. Serum gastrin and iCa concentrations were not correlated (P = .12).

Conclusions and Clinical Importance: Mild elevations in serum gastrin concentration may be seen in dogs with PHPT. Gastrin is not correlated with iCa concentration and does not decrease following PHPT treatment.