(C43) Comparison of the Clinical Utility of Del-Nido Cardioplegia and St. Thomas Solution with Cardiac Troponin-I

Abstract:

Background: Myocardial protection techniques in open-heart surgery have yet to be well-researched and standardized in veterinary medicine. Recently, del-Nido cardioplegia has been reported as a new technique in humans.
Hypothesis/

Objectives: This prospective study aimed to compare the utility of del-Nido cardioplegia with the conventional technique for mitral valve repair (MVR) in dogs and assessed myocardial damage using cardiac troponin-I (cTnI).
Animals: Forty client-owned dogs eligible for MVR were randomly divided into Group C (conventional technique) and Group D (del-Nido). Consent for the study was obtained from owners beforehand.

Methods: Group C used St. Thomas solution with 50% blood and potassium (40–50 mEq/L) every 10 minutes. Group D used the del-Nido cardioplegic technique, administered once or only when required, containing 20% blood, lidocaine (125 mg/L), and potassium (30 mEq/L). The levels of cTnI were assessed four times (before surgery and 2, 12, and 24 hours after surgery).

Results: There were no differences between the two groups regarding operative time, cardiopulmonary bypass time, or aortic cross-clamping time during the procedure. However, the time from declamping to the return of sinus rhythm was shorter in Group D. There were no significant differences in cTnI levels between the groups at any time.
Conclusions and clinical importance: In conclusion, both techniques in this study facilitated the safe performance of MVR: the lack of a difference in cTnI levels after surgery indicates that postoperative myocardial damage was comparable. However, the patients with del-Nido cardioplegia had a smoother resumption of sinus rhythm following surgery.