(C34) Association between Mitral Insufficiency Echocardiographic (MINE) Score and Mitral Valve Repair Outcome

Abstract:

Background: Mitral valve repair (MVR) could be a curative treatment for myxomatous mitral valve disease (MMVD) in dogs. However, the optimal timing for surgery is not known. Mitral insufficiency echocardiographic (MINE) score is an easy-to-use echocardiographic based classification used to assess the severity of MMVD in dogs for medical treatment.
Hypothesis/

Objectives: We hypothesized that the MINE score can be used for estimating the outcome of MVR.
Animals: We retrospectively analyzed the data of dogs with MMVD that underwent MVR at our institute from February 2017 to December 2020. We excluded cases that did not have enough data required for calculating the MINE score.

Methods: Echocardiographic variables were used to classify the cases into four stages preoperatively using the MINE scoring system: mild (score: 4-5), moderate (score: 6-7), severe (score: 8-12), and late (score: 13-14). Thoracic radiographs and echocardiography were evaluated in the preoperative period, 6- and 12-months post-surgery.

Results: The study included 897 dogs (mild = 16, moderate = 121, severe = 679, late = 81). The higher the disease stage, the larger the heart size both pre- and post-surgery. The four groups did not have difference in two-year survival rate for all-cause mortality derived by Kaplan-Meier curve: 92%, 77%, 85%, and 87%, respectively (P = 0.52; Log-rank test).
Conclusions and clinical importance: The MINE score can be used to predict the extent of cardiac reverse remodeling. However, it is unrelated to postoperative mortality. Therefore, estimating surgical outcomes require comprehensive factors, including clinical signs, arrhythmia, and medications.