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ACVIM Resident Research Award Eligible
ACVIM Resident Research Award Eligible
Additional Fees May Be Required
Additional Fees May Be Required
By Invite Only
By Invite Only
Capturing for On Demand
Capturing for On Demand
Cardiology Research Abstract Award Eligible
Cardiology Research Abstract Award Eligible
ERC Approved Lecture for ACVIM Residency
ERC Approved Lecture for ACVIM Residency
ePoster
ePoster
Livestream
Livestream
One Health
One Health
Pre-Registration Required
Pre-Registration Required
RACE-Approved
RACE-Approved
Research Abstract
Research Abstract
Specialty Symposium
Specialty Symposium
State-of-the-Art (SOTA) Presentation
State-of-the-Art (SOTA) Presentation
Veterinary Technician
Veterinary Technician
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Small Animal Internal Medicine

Category: Research Abstract - ePoster

Effectiveness of clopidogrel in preventing post-operative hypercoagulability in dogs undergoing splenectomy for splenic masses

(HM10) Effectiveness of Clopidogrel in Preventing Post-operative Hypercoagulability in Dogs Undergoing Splenectomy for Splenic Masses

Thursday, June 15, 2023
12:45 PM – 1:00 PM ET
Location: Solutions Center Poster Park - Kiosk 6
ePoster

    Research Abstract – ePoster Presenter(s)

  • Joonghyun Song, DVM, PhD, DKCVIM (he/him/his)

    Prof.
    Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea
    Yuseong-Gu, Taejon-jikhalsi, Republic of Korea

Abstract:

Background: Dogs that had undergone splenectomy are predisposed to fatal thrombotic conditions. Marked thrombocytosis has been well-known as a risk factor for post-splenectomy hypercoagulability.

Objective: To determine the preventive effect of clopidogrel on post-operative hypercoagulability during the first 2 weeks after splenectomy in dogs with splenic masses by platelet counts (PCs) and thromboelastographic (TEG) values.

Animals: Twelve dogs had undergone splenectomy. 7 dogs received no treatment (group A) and 5 dogs were treated with clopidogrel (group B).

Methods: Prospective study. Blood samples were collected on the day of surgery and 2, 7, and 14 days after splenectomy in both groups. In group B, TEG was performed on the same days. Clopidogrel was loaded at 10 mg/kg on day 2 and continued 2 mg/kg until day 14.

Results: In group A, there was a significant elevation of PCs on day 7 (P = 0.007) and day 14 (P = 0.001) compared to day 0. In group B, the PCs were significantly elevated on day 7 (P = 0.032) but no significant difference was found on day 14 compared to day 0. PCs on day 14 were significantly higher in group A than group B (P = 0.03). In TEG analysis, no significant differences were found in the K and α-angle values at all postoperative assessment points compared to day 0.

Conclusion and clinical importance: Marked thrombocytosis was evident during the first 2 weeks after splenectomy. Clopidogrel may have preventive effects of thrombocytosis and related-hypercoagulability in dogs undergoing splenectomy for splenic masses.