Abstract: Background: Sheep suffer from abomasal ulcers caused by factors like diet, non-steroidal anti-inflammatory drug (NSAID) treatment, and stress with limited therapies. Pantoprazole is a proton pump inhibitor (PPI) used for gastric ulcers, gastritis, and esophagitis in humans, adn can be administered by injection. Objectives: The objectives of this study were to determine the pharmacokinetics of pantoprazole after intravenous (IV) and subcutaneous (SC) administration, as well as to determine the effect of abomasal pH after administration. Animals: Four adult ewes, with abomasal cannulations. Methods: Ewes were administered a 1 mg/kg IV or SC dose of pantoprazole once daily for three consecutive days. Blood samples were collected from the ewes over 24 hours after the first administration, and abomasal fluid samples were collected over 96-hours. Plasma concentrations were analyzed via reversed-phase liquid chromatography. Data was interpreted with commercial software. Results: Pantoprazole was eliminated rapidly, with a 3.3 hour IV elimination half-life after IV. Both routes of administration had similar values for Area under the Curve: 17,766 hr*ng/mL (IV), 14,961 hr*ng/mL (SC) with a SC bioavailability of 88%. The abomasal fluid pH was significantly (P < 0.05) higher than pre-pantroprazole pH levels up to 8 hours after dosing on all three days for both treatments. Conclusions: Pantoprazole offers a potential therapy for gastroprotection in sheep . Similarities in IV and SC administration parameters suggests that SC administration may be efficacious enough to allow for easier dosing for practitioners and clients.
Learning Objectives:
Understand the study design of this investigation into the pharmacokinetics and pharmacodynamics of pantoprazole in sheep after intravenous and subcutaneous dosing.
Utilize intravenous pantoprazole for sheep where gastroprotection is a concern.
Utilize subcutaneous pantoprazole for sheep where gastroprotection is a concern.
