Abstract: Background: Transcatheter therapeutics have revolutionized management of patent ductus arteriosus (PDA) in children and animals. Further understanding of interventions for PDA across species may help improve outcomes for both. < br>< br>Hypothesis/Objectives: To describe characteristics and outcomes of PDA in patients undergoing transcatheter occlusion in pediatric and veterinary populations. < br>< br>Animals: 202 human patients from two pediatric cardiology centers and 106 dogs from three veterinary cardiology centers.< br>< br>Methods: Multicenter, retrospective review analyzing data of PDA patients between July 1, 2019 – June 30, 2021. Demographics, procedural characteristics, and outcomes were assessed. < br>< br>Results: Active or historical congestive heart failure was present in 45/202 (23%) humans and 19/106 (18%) dogs prior to catheterization (p=0.40). A transvenous approach from the right femoral vein was most common in 173/202 (86%) humans, compared to a transarterial approach using the right femoral artery in 101/106 (95%) dogs. Anticoagulant use during human intervention 165/165 (100%) significantly differed from canine intervention 2/103 (2%) (p< 0.0001). Vascular closure techniques differed with manual compression in all humans versus vessel ligation in 76 (73%) and vessel repair in 25 (24%) dogs following vascular cut-down; an additional 2 (2%) dogs underwent suture-based percutaneous closure and 1 dog (1%) manual compression (p< 0.0001). Successful intervention (appropriate device deployment) was seen in 98% of humans compared to 93% of dogs (p=0.051). < br>< br>Conclusions: Humans and dogs have similar success rates during transcatheter PDA occlusion. Roughly 1 in 5 patients of both species have congestive heart failure at the time of catheterization. Anti-coagulation is more commonly used in humans than dogs.
