Clinical Applications of Immunothrombosis and 'Omics in Sepsis (Planned by VCCIS)

Immunothrombosis describes the crosstalk between the generation of neutrophil extracellular traps (NETs) and pathologic thrombus formation that can occur in critical illnesses like sepsis. We will review this phenomenon, discuss ways to identify it in clinical patients and outline what potential future therapeutic options we might have to target this process. Advances in ‘Omics technology are improving our understanding of the individual host responses to infection that are defining subsets of sepsis. These improvements in understanding offer the tantalizing prospect of individualized medicine targeted to individual physiology. We will discuss some of these new developments, look for correlations in the veterinary field and ask whether individualized medicine for sepsis is something to which we can aspire?