Abstract: Background: Insulin dysregulation is the key component of equine metabolic syndrome (EMS) with management regimens focus on improving insulin sensitivity. In dogs and humans, the combination of leucine and pyridoxine has been shown to aid in weight reduction and improve insulin sensitivity. However, the effect of these supplements have not been evaluated in horses. Objective: Determine if the combination of leucine and pyridoxine would improve EMS biochemical parameters. Animals: A total of 38 ponies across five farms were enrolled in a 60 day trial. Methods: Ponies were blocked by farm, age and sex matched, and randomly assigned to the supplement (n=20) or placebo (n=18) group. Ponies were excluded if they were on medications or supplements labeled for the management of EMS. Ponies were evaluated using a two day testing protocol starting on day -1, 7, 30 and 60. On day one, ponies were weighed on a scale, baseline measurements (insulin, triglycerides, non-esterified fatty acids, adiponectin and leptin) were drawn, and a two-step insulin tolerance test was performed. On day 2, an oral sugar test was performed using 0.45ml/kg Karo Light Corn Syrup. Chi square analyses and pairwise comparison of the estimated marginal means were performed. Results: Ponies in the supplement group lost more weight (≥2% body weight; p< 0.04) and had a larger reduction in their max insulin concentration post oral sugar test (≥40% decrease; p< 0.03) compared to the placebo group. Conclusion: These data suggest that this combination supplement may be used to aid in the management of EMS.
.jpg "Elaine M. Norton, DVM, MS, PhD, DACVIM (LAIM) photo")
