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ACVIM Resident Research Award Eligible
ACVIM Resident Research Award Eligible
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Cardiology Research Abstract Award Eligible
Cardiology Research Abstract Award Eligible
ERC Approved Lecture for ACVIM Residency
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Evaluation ViewAttendees 18

Cardiology

C05 - Prospective Characterization of Electrocardiographic, Echocardiographic, and Natriuretic Peptide Changes Following Radioiodine Therapy in Hyperthyroid Cats

Thursday, June 15, 2023
10:00 AM – 10:15 AM ET
Location: PCC 201C
CE: 0.25
ACVIM Resident Research Award Eligible Cardiology Research Abstract Award Eligible Research Abstract
Abstract:
Background:
The pro-arrhythmic effects of thyroid hormones are well documented in people. Multiple ECG abnormalities have been reported in hyperthyroid cats Few studies have evaluated echocardiographic and cardiac biomarker parameters pre- versus post-radioiodine treatment for feline hyperthyroidism. It is unknown whether ECG abnormalities improve post-radioiodine therapy in cats. 

Objectives:
Evaluate 5-minute ECGs in hyperthyroid cats undergoing I-131. The hypothesis was that radioiodine treatment would result in improvement of supraventricular and/or ventricular arrhythmias. Additional objectives were to characterize ECG, echocardiographic, and N-terminal pro-B-type natriuretic peptide (NT-proBNP) changes over time.

Animals:
Client-owned cats undergoing I-131; 32 cats were initially eligible for inclusion. Six cats were excluded, 26 cats were enrolled. One cat did not complete the final evaluation due to euthanasia for non-cardiac reasons.

Methods:
Single-center, prospective study completed June 2021-January 2023. Initial evaluation performed immediately prior to I-131: physical exam, blood pressure, echocardiogram, NT-proBNP, thyroid level (T4), and 5-minute 6-lead ECG. Recheck blood pressure, ECG, T4, and NT-proBNP were performed 4-6 weeks later. Final evaluation 4-6 months post radioiodine therapy repeated all initial diagnostics.

Results:
Preliminary analyses revealed a reduction in T4 following I-131 was associated with a statistically significant reduction in left atrial size (2-D left atrial to aortic root ratio), left ventricular free wall thickness, left ventricular fractional shortening, NT-proBNP, weight, and average heart rate. There was a significant reduction in the number of patients with arrhythmias.

Conclusions:
Prospective studies utilizing 24-hour Holter or telemetry monitoring are needed to further characterize arrhythmias in hyperthyroid cats undergoing radioiodine therapy.