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ACVIM Resident Research Award Eligible
ACVIM Resident Research Award Eligible
Additional Fees May Be Required
Additional Fees May Be Required
By Invite Only
By Invite Only
Capturing for On Demand
Capturing for On Demand
Cardiology Research Abstract Award Eligible
Cardiology Research Abstract Award Eligible
ERC Approved Lecture for ACVIM Residency
ERC Approved Lecture for ACVIM Residency
ePoster
ePoster
Livestream
Livestream
One Health
One Health
Pre-Registration Required
Pre-Registration Required
RACE-Approved
RACE-Approved
Research Abstract
Research Abstract
Specialty Symposium
Specialty Symposium
State-of-the-Art (SOTA) Presentation
State-of-the-Art (SOTA) Presentation
Veterinary Technician
Veterinary Technician
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Oncology

Category: Research Abstract - ePoster

(O27) Urinary Exosomal Nuclear Matrix protein-22 as a Novel Liquid Biopsy of Urothelial Carcinoma Dogs

Thursday, June 15, 2023
6:45 PM – 7:00 PM ET
Location: Solutions Center Poster Park - Kiosk 4
ePoster

    Research Abstract – ePoster Presenter(s)

  • Ju-Hyun AN, DVM, PhD (she/her/hers)

    Assistant professor/Veterianry Emergency and Critical Care Medicine
    College of Veterinary Medicine, Kangwon National University
    Chuncheon, Kangwon-do, Republic of Korea

Abstract:

Background: Nuclear matrix protein (NMP) 22 is found in higher-than-normal amounts in the urine of some types of cancer patients, including bladder cancer, and various studies are underway to use it as a cancer diagnostic tool. In particular, exosomes in urine are stable due to the lipid bilayer and resistant to enzymes and uric acid. Therefore, the use of urinary exosomes as a diagnostic and prognostic biomarker for urothelial carcinoma (UC) is currently being studied, but no study has been conducted to confirm NMP-22 in urinary exosomes.
Hypothesis/

Objectives: We aimed to investigate the clinical usefulness of urinary exosomal NMP-22 in diagnosing urothelial carcinoma in dogs.
Animals: Total 30 dogs (UC group, n=6; UC suspected, n=6, control group, n=17) were included in the analysis

Methods: Among the canine patients who visited the veterinary hospital, urine was collected from patients who obtained consent from their owners, and after exosome was isolated from the urine, NMP-22 was measured using ELISA.

Results: Compared to the control group and the UC suspected group, a significant difference was confirmed in the concentration of NMP-22 in urine exosomes in the UC group.
Conclusions and Clinical importance: It was confirmed that NMP-22 was significantly increased in exosome urine of dogs diagnosed with UC, suggesting that exosome NMP-22 can be considered as one of the liquid biopsies tools for diagnosing UC in dogs.